Antiviral Activity of Quercetin-3-Glucoside Against Non-Polio Enterovirus

Non-polio enteroviruses (NPEVs) are primary causative agents of aseptic meningitis, encephalitis, hand, foot and mouth disease (HFMD), myocarditis in infants children immunocompromised individuals. However, there no approved treatments for NPEVs. It has been reported that flavonoids abundantly found plants have antiviral activities. In this study, we explored the potential quercetin-3-glucoside (Q3G), a natural flavonoid, against NPEVs such as coxsackievirus A16 B3 (CVA16 CVB3), enterovirus 71 (EV71), human rhinovirus 1B (HRV 1B). Q3G showed potent activity CVA16, CVB3, EV71, HRV1B by suppressing expression viral RNA at early stages infection. Therefore, inhibits replication cycle may provide an essential alternative treating HRV1B.